Register Calendar Latest Topics

  Profile Picture  
Profile Picture
This user has not added any photos yet.
  Contact Information  
Email: Email MiguelGF
Private Messaging: Disabled
  General Information  
Member Title: Junior Member
Name: Miguel Godinho Ferreira
Birthday (Age): May 22,1970 (47 years)
Gender: Male  
Location: Lisbon, Portugal  
About Me: Despite the crucial work performed in the mouse model system over the past decade, major disparities in telomere length between humans and mice (mouse telomeres are 5–-10 times longer than those of humans) remain as an obstacle as to interpret the relevance of these studies for human health. Namely, the telomerase-deficient mouse showed no relevant phenotypic differences from its normal siblings, suggesting that—at least for laboratory mouse strains—aging and cancer are not direct consequences of the minor telomere shortening occurring throughout their lives.

To analyze the consequences of telomere dysfunction in the whole organism, we have chosen to work with zebrafish, an organism with naturally shorter telomeres. Our goal is to use the knowledge acquired on the molecular nature of telomere protection to understand the consequences of its failure at the organism level. Our base hypothesis implies that telomere dysfunction signals a cascade of events that triggers cellular senescence and organism aging. We will test this idea by manipulating telomere dysfunction (in a time- and tissue-specific manner), using transgenic zebrafish. Our vision is that enabling timely telomere protection in a few key tissues will postpone aging in the whole organism and, as a consequence, reduce the frequency of age-associated diseases, in particular, cancer.

We have two main projects running in our lab. The first concerns the broader question of whether telomere defects are cell-autonomous or, alternatively, whether telomere dysfunction acquired in specific tissues somehow signals other organs, thereby coordinating organism aging. The second question relies on a more straightforward use of telomerase-mutant zebrafish to genetically determine the stage at which telomerase expression is required during cancer development, using an established model of invasive melanoma.  
  Account Information  
Status: Pending approval
Date Registered:
Online Status: Offline 
Total Posts: 0
Reputation: 0
Find Posts: Find all posts by MiguelGF
Find all topics started by MiguelGF
Last Post:
Last visit:

Create your own forum with Website Toolbox!